Erectile Dysfunction? Mermaid’s Skin & Wellness can Help.
Located in Downtown Delray, our clean and tastefully designed office is set up to provide the most discreet appointment able.
Trimix Injections include a mixture of 3 drugs. These are Papaverine,
Alprostadil/Prostaglandin, and Phentolamine. Trimix injections are considered
as one of the most powerful classes of anti-erectile dysfunction medications.
DOSAGE:
The initial dosage of Trimix Injections should be around 0.05cc to 0.2cc which should depend on a patient’s level of erectile dysfunction.
You should wait for at least 48 hours before you increase your dosage.
After this, you can increase your dosage by 0.025cc to 0.05cc until you arrive at a satisfactory level. The maximum dose should be 0.5cc.
The initial dose is kept low in order to avoid a prolonged erection, so you should not be discouraged if you get poor results within your first few attempts.
Pharmacologic Category: Anti-erectile dysfunction preparation: vasodilator, prostglandin, & alpha-adrenergic receptor antagonist.
General Information
Tri-mix is administered as a penile self-injection, typically considered to be the most powerful class of anti-erectile dysfunction agents.1 While the components of Tri-mix are, on there own, indicated for a vast number of different conditions (papaverine, phentolamine, PGE1 monographs), the practice of bringing them together in concert to treat erectile dysfunction has become commonplace in sexual medicine and is now considered to be the go-to treatment if conventional PDE5 inhibitors are contraindicated or nonresponsive.21 and is now considered the go-to treatment if a patient is not responsive to conventional PDE5 inhibitors such as Viagra or Cialis.1
Indications: Tri-Mix is indicated in the treatment of erectile dysfunction in males. Tri-Mix contains three drugs from complimentary classes designed to act synergistically, mixed into a sterile injection. They are:
Papaverine: A drug that causes blood vessels to expand (vasodilator); it produces an erection by allowing for increased blood flow to the penis. Papaverine interacts with adenylate cyclase resulting in increased cyclic adenosine monophosphate (cAMP) production, ultimately resulting in increased erectile capacity by relaxation of penile smooth muscle 3. This drug was one of the first effective therapies for erectile dysfunction administered by penile injection 4. Papaverine works by inhibiting phosphodiesterase nonspecifically, there are also multiple other mechanisms by which this drug acts to improve erectile capacity 5. The current body of medical literature has not established the predominant mechanism by which papaverine works. The multi-mechanistic manner by which this drug acts may be concentration dependent. Experimental data, performed in-vitro, displays papaverine acting to relax the penile arteries, the cavernosal sinusoids, and the penile veins 6. Experiments carried out in dogs display papaverine’s ability to decrease the resistance to arterial inflow while also increasing the resistance to venous outflow 7. Papaverine’s ability to decrease resistance to venous outflow has been replicated in clinical studies 8. A veno-occlusive mechanism may be responsible for the aforementioned findings.
Interested in seeing our healthcare provider to find out if TRIMIX is right for you?
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